Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting. Cantargia AB (“Cantargia”) meddelade idag att nya prekliniska resultat, som stödjer kombination av den kliniskt studerade antikroppen CAN04 med platinabaserade cellgifter, kommer presenteras vid två posterpresentationer på 2020 Annual

22 okt 2018 Antikroppen CAN04 tolererades väl och 6 mg/kg är en säker dosEffekt på biomarkörer och 5 av 13 utvärderbara patienter uppnådde stabil

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Can04 data

Cantargia AB (“Cantargia”) today presented new preclinical data Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting. Cantargia AB (“Cantargia”) meddelade idag att nya prekliniska resultat, som stödjer kombination av den kliniskt studerade antikroppen CAN04 med platinabaserade cellgifter, kommer presenteras vid två posterpresentationer på 2020 Annual During 2019, Cantargia reported positive preclinical data on the combination of CAN04 and platinum-based compounds and these studies together with new data from Cantargia will be presented at AACR. The results show synergistic/additive effects of combining CAN04 with the three different registered platinum-based therapies: cisplatin, carboplatin or oxaliplatin in tumor bearing mice. CAN04 increased the anti-tumor effects in mice when combined with different registered platinum-based therapies (cisplatin, carboplatin or oxaliplatin) in either a patient-derived NSCLC model or mouse colon cancer model. Enhanced effects of CAN04 was also observed in combination with two commonly used platinum doublets, cis/gem and oxaliplatin/5-FU. CAN04 studeras i en öppen klinisk fas I/IIa-prövning, CANFOUR, som undersöker första linjens kemoterapikombination med två olika standardregimer hos 31 patienter med NSCLC (gemcitabin/cisplatin) och 31 patienter med PDAC (gemcitabin/nab-paclitaxel), samt monoterapi hos patienter i sen fas (www.clinicaltrials.gov).

Cantargia AB, a biotechnology company, announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 per cent of patients with bladder cancer.

Det bekräftar Cantargias engagemang att förse patienter som har livshotande sjukdomar med nya, innovativa och säkra terapeutiska möjligheter", sa Göran Forsberg, VD på Cantargia. Cantargia AB: Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting Publicerad: 2020-05-15 (Cision) Måndag 4 maj 2019-06-02 · CAN04 is a humanized and antibody-dependent cellular cytotoxicity (ADCC)-enhanced IgG1 antibody targeting IL1RAP with two modes of action: blocking IL-1 alpha and beta signaling and triggering ADCC. This study included 22 patients with non–small cell lung cancer (NSCLC; four patients), pancreatic ductal adenocarcinoma (six patients), or colorectal cancer (12 patients). Cantargia’s antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody Dependent Cellular Cytotoxicity and blockade of interleukin 1 signaling.

Oct 14, 2020 In this review, we have discussed about the recent outcomes of employing AI in multi-omics data analysis of different types of cancer. Based on

2019-08-23 · Cantargia har meddelat nya positiva prekliniska data för bolagets antikropp CAN04. Målmolekylen för CAN04, IL1RAP, har påvisats på cancercellerna hos cirka 80 procent patienterna med urinblåsecancer. CAN04 prissätts till ca 65 000 USD. Kostnaden för ett års cancerbehandling med Keytruda uppgår till cirka 130 000 USD. Vi tror dock att en interleukin-blockerande antikropp som CAN04 kommer i fråga först efter en genotypning av tumörresistensen som visar på interleukin-känslighet. Vi Nya fas I kliniska data på antikroppen CAN04 (nidanilimab) presenterades idag som en muntlig presentation på konferensen ”2019 ASCO Annual Meeting”. Data från 22 patienter visar att CAN04-behandling är förenat med god säkerhet. Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab).

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4 out of 7 evaluable patients with metastatic pancreatic cancer (PDAC) and 2 out of 3 patients with metastatic non-small cell lung cancer (NSCLC), including 1 patient with complete response (CR), had objective responses. Cantargia AB, a biotechnology company, announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 per cent of patients with bladder cancer. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling.

The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. reported data from 1 patient in the Phase I/IIa CANFOUR trial showing that once-weekly IV CAN04..adverse events. The first part of the open-label, European trial is evaluating escalating doses of CAN04..pancreatic cancer, colorectal cancer or triple-negative breast cancer (TNBC), and the second part will evaluate CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP).
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Cantargia announce positive preclinical data on CAN04 in bladder cancer. Cantargia AB today announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer.

4 out of 7 evaluable patients with metastatic pancreatic Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment. The results from this trial, together with the data generated on CAN04 in combination with platinum-based chemotherapy, will be the basis for studies of CAN04 in combination with pembrolizumab and 1175 Views The company has announced new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer.